Name: Chicken Spaghetti Casserole
Prep time: 15 min
Cook time: PT-485560H9M35S
Total time: PT-485560H9M35S
Cuisine: American
Ingredients: 2 cups cooked, shredded chicken (rotisserie chicken works great!); 8 oz spaghetti (or any pasta you like); 1 can (10.5 oz) cream of chicken soup (or mushroom soup for a twist); 1/2 cup sour cream; 1 cup shredded cheddar cheese; 1 cup shredded mozzarella cheese; 1/2 cup milk; 1/2 tsp garlic powder; 1/2 tsp onion powder; 1/4 tsp black pepper; 1/2 cup diced bell peppers (optional); 1/4 cup chopped green onions or parsley (optional for garnish)

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This Chicken Spaghetti Casserole is a creamy, comforting dish that's perfect for family dinners or meal prep. Tender shredded chicken combines with cheesy pasta and a rich, flavorful sauce, baked until bubbly and golden on top. It’s easy to make, versatile, and hits all the cozy food cravings I love.

Ingredients

2 cups cooked, shredded chicken (rotisserie chicken works great!)

8 oz spaghetti (or any pasta you like)

1 can (10.5 oz) cream of chicken soup (or mushroom soup for a twist)

1/2 cup sour cream

1 cup shredded cheddar cheese

1 cup shredded mozzarella cheese

1/2 cup milk

1/2 tsp garlic powder

1/2 tsp onion powder

1/4 tsp black pepper

1/2 cup diced bell peppers (optional)

1/4 cup chopped green onions or parsley (optional for garnish)

(Tip: You'll find the full list of ingredients and measurements in the recipe card below.)

Directions

Preheat the oven to 350°F (175°C). Grease a 9x13" baking dish.

Cook the spaghetti according to package directions. Drain and set aside.

In a large bowl, combine the cream of chicken soup, sour cream, milk, garlic powder, onion powder, black pepper, and 1/2 cup of the cheddar cheese. Mix well.

Stir in the shredded chicken and diced bell peppers if using.

Toss the cooked spaghetti with the sauce mixture until everything is well-coated.

Pour the pasta mixture into the prepared baking dish. Top evenly with the mozzarella cheese and the remaining cheddar cheese.

Bake for 25-30 minutes, until the cheese is melted, bubbly, and the casserole is heated through.

Sprinkle with chopped green onions or parsley before serving for a fresh finish.

Servings and timing

This recipe serves about 6 people. Prep time takes roughly 15 minutes, and the baking time is about 25-30 minutes, making the total time around 45 minutes from start to finish.

Variations

I like to switch things up by adding a can of green chilies for a little heat or tossing in sautéed mushrooms or fresh spinach for extra flavor and nutrition. For a crunchy contrast, sprinkling breadcrumbs or crushed crackers on top before baking creates a crispy golden topping I can’t resist.

Storage/reheating

I usually store any leftovers in an airtight container in the refrigerator for up to 3-4 days. To reheat, I cover the casserole with foil and warm it in the oven at 350°F (175°C) for about 15-20 minutes or until heated through. You can also microwave individual servings, but I prefer the oven to keep the texture just right.

FAQs

Can I use other types of pasta besides spaghetti?

Absolutely! I’ve made this casserole with penne, rotini, or elbow macaroni — any pasta shape that holds sauce well works great.

Is it possible to make this recipe gluten-free?

Yes, I substitute regular pasta with gluten-free pasta and make sure to use a gluten-free cream of chicken soup to keep it safe for gluten-sensitive eaters.

Can I prepare this casserole ahead of time?

Definitely. I sometimes assemble the casserole the night before, cover it tightly, and refrigerate it. When ready, I bake it a bit longer, around 35-40 minutes, to ensure it’s hot throughout.

What can I use instead of cream of chicken soup?

If you don’t have cream of chicken soup, a homemade white sauce made from butter, flour, and milk can be a good substitute, or you can use cream of mushroom soup for a different flavor.

How do I make this casserole dairy-free?

To make it dairy-free, I swap the cheeses and sour cream with plant-based alternatives and use a dairy-free creamy soup or homemade sauce. The flavor will be different but still tasty.

Conclusion

Chicken Spaghetti Casserole is one of those dishes I keep coming back to because it’s simple, comforting, and endlessly adaptable. Whether I’m feeding a crowd or looking for a cozy solo dinner, it delivers every time. With a creamy sauce, tender chicken, and gooey cheese, this casserole is a reliable classic I always enjoy making and sharing.

Recipe:

Chicken Spaghetti Casserole

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Author: Cheryl
Total Time: 40-45 minutes
Yield: 6 servings
Diet: Low Fat

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Description

This Chicken Spaghetti Casserole is a creamy, comforting dish with tender shredded chicken, cheesy pasta, and a rich sauce baked until bubbly and golden. Perfect for family dinners or meal prep.

Instructions

Preheat the oven to 350°F (175°C). Grease a 9x13" baking dish.
Cook the spaghetti according to package directions. Drain and set aside.
In a large bowl, combine the cream of chicken soup, sour cream, milk, garlic powder, onion powder, black pepper, and ½ cup of the cheddar cheese. Mix well.
Stir in the shredded chicken and diced bell peppers if using.
Toss the cooked spaghetti with the sauce mixture until everything is well-coated.
Pour the pasta mixture into the prepared baking dish. Top evenly with the mozzarella cheese and the remaining cheddar cheese.
Bake for 25-30 minutes, until the cheese is melted, bubbly, and the casserole is heated through.
Sprinkle with chopped green onions or parsley before serving for a fresh finish.